Methadone for sale online, a pharmaceutical opioid, is currently marketed as oral concentrate (10 mg/ml), oral solution (5 and 10 mg/5ml), tablet (5, 10, and 40 mg), injection (10mg/ml) and powder (50, 100, and 500 mg/bottle for prescription compounding). According to the National Center for Health Statistics (NCHS) Health E-Stats publication, poisoning deaths increased 66% from 19,741 in 1999 to 32,691 in 2005. During the same time period, methadone deaths increased 468% to 4,462 (14% of all poisonings). In November 2006, the Food and Drug Administration (FDA) issued a public health advisory stating that methadone use in pain control may result in life-threatening cardiac and respiratory changes and deaths. FDA further advised that methadone doses for pain relief should be carefully selected, slowly titrated and carefully monitored by the prescribing physician. As of January 1, 2008, manufacturers of 40 mg methadone hydrochloride for sale online dispersible tablets have voluntarily agreed to restrict distribution of this formulation to only hospitals and those facilities authorized for detoxification and maintenance treatment of opioid addiction. The 40mg methadone for sale online product is not FDA approved for use in the management of pain