This combination medication contains two active ingredients: oxycodone and naloxone. Oxycodone belongs to the group of medications known as opioid analgesics (narcotic pain relievers). Naloxone belongs to a group of medications known as opiate antagonists and is used to lessen the constipation caused by oxycodone. This combination is used to treat severe pain in adults who require 24-hour pain relief for several days or more. It should only be used by people for whom other treatment options are ineffective or not tolerated.
Oxycodone decreases pain by working on the central nervous system. Naloxone works by blocking receptors in the gut that slow the elimination of the stool. This medication relieves pain for up to 12 hours.
 
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